y-of-nanopore-dna-sequencing-using-a-time-varying-cross-membrane">Increasing the accuracy of nanopore DNA sequencing using a time-varying cross membrane

Increasing accuracy diagram

Summary

We used DNA's inherent flexibility to create a more 'continuous scan' of the DNA as it moves through the nanopore to increase sequencing accuracy. This innovative approach significantly improves the reliability of nanopore DNA sequencing.

Authors

M.T. Noakes, H. Brinkerhoff, A.H. Laszlo, I.M. Derrington, K.W. Langford, J.W. Mount, J.L. Bowman, K.M. Doering, B.I.Tickman, J.H. Gundlach

Publication

Published in Nature Biotechnology

DOI: 10.1038/s41587-019-0096-0

Technical Innovation

Our approach leverages:

DNA's natural flexibility for improved measurement
Time-varying cross membrane voltage
Continuous scanning method
Enhanced sequencing reliability

Key Findings

The research demonstrates:

Improved nanopore DNA sequencing accuracy
Novel continuous scanning methodology
Applications for genomic research

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