Decoding Long Nanopore Sequencing Reads

First demonstration of multi-kilobase reads of genomic DNA using the MspA nanopore, advancing long-read sequencing capabilities.

Detection and Mapping of 5-methylcytosine

Demonstration of epigenetic DNA methylation detection using the nanopore MspA, advancing our understanding of epigenetic markers.

Increasing the accuracy of nanopore DNA sequencing using a time-varying cross membrane

A breakthrough in DNA sequencing accuracy: leveraging DNA's natural flexibility to create a continuous scanning method that significantly improves nanopore sequencing reliability.

Nanopore DNA Sequencing with MspA

Demonstration of MspA nanopore's sensitivity for DNA sequencing and development of methods to enable practical sequencing applications.

Nanopore tweezers show fractional-nucleotide translocation in sequence-dependent pausing by RNA polymerase

With Single-Molecule Picometer Resolution Nanopore Tweezers we measure how a RNA polymerase moves with exquisite detail

Reading DNA with the MspA Nanopore

First demonstration of enzyme-controlled motion of DNA through a nanopore, showing the potential for high-throughput nanopore-sequencing.

Single Molecule DNA detection with an engineered MspA protein nanopore

We engineered the nanopore MspA and demonstrated that this enables DNA to move through it

Subangstrom Measurements of Enzyme Function

Using the exquisite sub-angstrom precision of the MspA nanopore to directly measure sub-catalysis reaction steps for the Hel-308 helicase.