ents [Analyte Sequencing with Nanopores](https://patents.google.com/patent/US20130146457/de) United States Patent 9588079 (2011) 14:T6e9,

Reading DNA with the MspA Nanopore

Reading DNA

Summary

We achieved a significant milestone by demonstrating the first enzyme-controlled motion of DNA through a nanopore. This breakthrough directly showed the potential for high-throughput nanopore-sequencing.

Authors

Manrao, E., Derrington, I.M., Laszlo, A., Langford, K., Hopper, M., Gilgren, N., Pavlenok, M., Niederweis, M., Gundlach, J.

Publication

Published in Nature Biotechnology
DOI: 10.1038/nbt.2171

Technical Innovation

Our research demonstrated:

Precise control of DNA movement through MspA
Integration of enzyme mechanics with nanopore technology
Scalable approach to DNA sequencing

Key Findings

First demonstration of controlled DNA motion through nanopore
Enzyme-mediated DNA translocation
Proof of concept for high-throughput sequencing

Impact

This work has led to:

New paradigms in DNA sequencing technology
Enhanced understanding of enzyme-DNA interactions
Foundation for commercial nanopore sequencing platforms

Patents

Analyte Sequencing with Nanopores
United States Patent 9588079 (2011)

15:{"name":"Ian Derrington","title":"Principal Data Scientist","image":"/images/authors/i_logo.png"} 17:["DNA Reading","Nanopore","MspA","D